Therapeutic Time Window of Methylprednisolone in Acoustic Injury

Authors:
  • HMHidekazu Murashita
    Hidekazu Murashita
  • SSShuhei Sakai
    Shuhei Sakai
  • THTomofumi Hoshino
    Tomofumi Hoshino
  • IUIsao Uemaetomari
    Isao Uemaetomari
  • AHAkira Hara
    Akira Hara
Publisher website
Google Scholar
Abstract
This study aims to investigate the therapeutic time window of methylprednisolone in acoustic injury. Although glucocorticoids have been widely used in the treatment of acoustic injury, the therapeutic time window of glucocorticoids in acoustic injury has never been examined. Mice were exposed to 4-kHz pure tone of 128-dB sound pressure level for 4 hours. Auditory brainstem response was examined before, immediately after, and 2 weeks after acoustic overexposure. Methylprednisolone significantly improved the auditory brainstem response threshold shifts 2 weeks after acoustic overexposure when it was administered before or immediately after acoustic overexposure, but not when administered 3 hours after acoustic overexposure. The present findings suggest that methylprednisolone possesses protective effects against acoustic injury of the cochlea with a short therapeutic time window.

This publication has 8 references indexed in Scilit: