Regulation of cell differentiation and function by the euchromatin histone methyltranserfases G9a and GLP
- 1 February 2016
- journal article
- review article
- Published by Canadian Science Publishing in Biochemistry and Cell Biology
- Vol. 94 (1) , 26-32
Abstract
The euchromatin histone methyltransferases (EHMTs) are an evolutionarily conserved protein family that are known for their ability to dimethylate histone 3 at lysine 9 in euchromatic regions of the genome. In mammals there are two EHMT proteins, G9a, encoded by EHMT2, and GLP, encoded by EHMT1. EHMTs have diverse roles in the differentiation of different tissues and cell types and are involved in adult-specific processes like memory, drug addiction, and immune response. This review discusses recent findings from rodent and Drosophila models that are beginning to reveal the broad biological role and complex mechanistic functioning of EHMT proteins.Keywords
This publication has 55 references indexed in Scilit:
- Non-histone protein methylation as a regulator of cellular signalling and functionNature Reviews Molecular Cell Biology, 2014
- Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammationJournal of Clinical Investigation, 2014
- Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome miceDevelopmental Biology, 2014
- Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndromeHuman Molecular Genetics, 2012
- G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of Glucocorticoid Receptor target genesProceedings of the National Academy of Sciences, 2012
- Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5AProceedings of the National Academy of Sciences, 2012
- MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9aNature Communications, 2011
- Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout miceBehavioural Brain Research, 2010
- The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modulesNature Structural & Molecular Biology, 2008
- High-Resolution Profiling of Histone Methylations in the Human GenomeCell, 2007