Breakthroughs in the Health Effects of Plant Food Bioactives: A Perspective on Microbiomics, Nutri(epi)genomics, and Metabolomics
Open Access
- 13 September 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 66 (41) , 10686-10692
Abstract
Plant bioactive compounds consumed as part of our diet are able to influence human health. They include secondary metabolites like (poly)phenols, carotenoids, glucosinolates, alkaloids, and terpenes. Although much knowledge has been gained, there is still need for studies unravelling the effects of plant bioactives on cardiometabolic health at individual level, using cutting-edge high resolution and data-rich holistic approaches. The aim of this perspective paper is to review the prospects of microbiomics, nutrigenomics and nutriepigenomics, and metabolomics to assess the response to plant bioactive consumption while considering inter-individual variability. Insights for future research in the field towards personalized nutrition are discussed.Keywords
Funding Information
- European Cooperation in Science and Technology (FA1403)
This publication has 30 references indexed in Scilit:
- Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humansArchives of Biochemistry and Biophysics, 2018
- Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypesEuropean Journal of Nutrition, 2018
- Foodomics evaluation of bioactive compounds in foodsTrAC Trends in Analytical Chemistry, 2017
- Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants InvolvedAdvances in Nutrition, 2017
- Food and plant bioactives for reducing cardiometabolic disease risk: an evidence based approachFood & Function, 2017
- Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese individuals consuming pomegranate: A randomized clinical trialMolecular Nutrition & Food Research, 2017
- Addressing the inter‐individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reductionMolecular Nutrition & Food Research, 2016
- Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich ExtractsCurrent Obesity Reports, 2015
- Equol: History, Chemistry, and FormationThe Journal of Nutrition, 2010
- A human gut microbial gene catalogue established by metagenomic sequencingNature, 2010