Oxidase enzymes as sustainable oxidation catalysts
Open Access
- 12 January 2022
- journal article
- review article
- Published by The Royal Society in Royal Society Open Science
- Vol. 9 (1) , 211572
Abstract
Oxidation is one of the most important processes used by the chemical industry. However, many of the methods that are used pose significant sustainability and environmental issues. Biocatalytic oxidation offers an alternative to these methods, with a now significant enzymatic oxidation toolbox on offer to chemists. Oxidases are one of these options, and as they only depend on molecular oxygen as a terminal oxidant offer perfect atom economy alongside the selectivity benefits afforded by enzymes. This review will focus on examples of oxidase biocatalysts that have been used for the sustainable production of important molecules and highlight some important processes that have been significantly improved through the use of oxidases. It will also consider emerging classes of oxidases, and how they might fit in a future biorefinery approach for the sustainable production of important chemicals.Keywords
Funding Information
- Royal Society of Chemistry (E20-9653)
- UK Research and Innovation (MR/T019522/1)
This publication has 71 references indexed in Scilit:
- Flavoprotein oxidases: classification and applicationsApplied Microbiology and Biotechnology, 2013
- Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed DesymmetrizationJournal of the American Chemical Society, 2012
- The Putative Endoglucanase PcGH61D from Phanerochaete chrysosporium Is a Metal-Dependent Oxidative Enzyme that Cleaves CellulosePLOS ONE, 2011
- Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass componentsProceedings of the National Academy of Sciences, 2011
- Cleavage of cellulose by a CBM33 proteinProtein Science, 2011
- Enantioselective Oxidation of C–O and C–N Bonds Using OxidasesChemical Reviews, 2011
- Glycoprotein Labeling Using Engineered Variants of Galactose Oxidase Obtained by Directed EvolutionJournal of the American Chemical Society, 2011
- Redox Reactions Catalyzed by Isolated EnzymesChemical Reviews, 2011
- The Structure of Monoamine Oxidase from Aspergillus niger Provides a Molecular Context for Improvements in Activity Obtained by Directed EvolutionJournal of Molecular Biology, 2008
- A Chemo-Enzymatic Route to Enantiomerically Pure Cyclic Tertiary AminesJournal of the American Chemical Society, 2006