DIPHENYLHYDANTOIN HALF‐LIFE IN MAN AND ITS INHIBITION BY PHENYLBUTAZONE: THE ROLE OF GENETIC FACTORS

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Abstract
The diphenylhydantoin serum half‐life (DPHT/2) has been determined in 14 pairs of healthy young male twins, 7 identical and 7 fraternal. The mean intrapair variance was significantly less in identical than in fraternal twins, indicating that the individual variability in DPHT/2 is mainly due to genetic factors. A daily dose of 100 mg phenylbutazone for 5 or 6 days to 11 pairs of the twins greatly prolonged the DPHT/2. A significant correlation between the prolongation of the DPHT/2 and the serum phenylbutazone levels was found (r= + 0.586,pT/2 at identical phenylbutazone levels were demonstrated. There was, however, no difference in the mean intrapair variance of identical and fraternal twins and we conclude that the individual variability in the extent of impairment of DPH metabolism by phenylbutazone cannot be attributed to genetic influence.

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