Biosensing with DNAzymes

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Abstract
This article provides a comprehensive review of biosensing with DNAzymes, providing an overview of different sensing applications while highlighting major progress and seminal contributions to the field of portable biosensor devices and point-of-care diagnostics. Specifically, the field of functional nucleic acids is introduced, with a specific focus on DNAzymes. The incorporation of DNAzymes into bioassays is then described, followed by a detailed overview of recent advances in the development of in vivo sensing platforms and portable sensors incorporating DNAzymes for molecular recognition. Finally, a critical perspective on the field, and a summary of where DNAzyme-based devices may make the biggest impact are provided.
Funding Information
  • National Institute of Mental Health (MH110975)
  • National Institute of General Medical Sciences (GM124316)
  • National Institute of General Medical Sciences (GM141931)
  • Natural Sciences and Engineering Research Council of Canada (RGPIN-184073-18)
  • Natural Sciences and Engineering Research Council of Canada (RGPIN-2020-06401)

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