Spatial and temporal specification of neural fates by transcription factor codes
Open Access
- 1 November 2007
- journal article
- Published by The Company of Biologists in Development
- Vol. 134 (21) , 3771-3780
Abstract
The vertebrate central nervous system contains a great diversity of neurons and glial cells, which are generated in the embryonic neural tube at specific times and positions. Several classes of transcription factors have been shown to control various steps in the differentiation of progenitor cells in the neural tube and to determine the identity of the cells produced. Recent evidence indicates that combinations of transcription factors of the homeodomain and basic helix-loop-helix families establish molecular codes that determine both where and when the different kinds of neurons and glial cells are generated.Keywords
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