Predominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugal
Authors:
- Vera ManageiroVera Manageiro
- Eugénia FerreiraEFEugénia Ferreira
- Joana AlmeidaJAJoana Almeida
- Antibiotic Resistance Surveillance Program In Portugal (Arsip)A(Antibiotic Resistance Surveillance Program In Portugal (Arsip)
- Manuela CaniçaMCManuela Caniça
Open Access
- 1 June 2015
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 59 (6) , 3588-3592
Abstract
Among the 2,105 Enterobacteriaceae tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26 Klebsiella pneumoniae , 3 Escherichia coli , 2 Enterobacter aerogenes , and 3 Enterobacter cloacae isolates and 1 Klebsiella oxytoca isolate) were confirmed to be carbapenemase producers by the presence of 30 Tn 4401d- bla KPC-3 , 4 intI 3- bla GES-5 , and one intI 1- bla VIM-2 gene, alone or in combination with other bla genes. The dissemination of bla KPC-3 gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.Keywords
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