Monoclonality of Composite Large Cell Neuroendocrine Carcinoma and Mucinous Epithelial Tumor of the Ovary: A Case Study

Authors:
  • MTMasahiko Tsujimoto
    Masahiko Tsujimoto
  • SFShigeki Fujita
    Shigeki Fujita
  • IKIchiro Kunishige
    Ichiro Kunishige
  • YNYukihiro Nishio
    Yukihiro Nishio
  • RKRieko Kodama
    Rieko Kodama
  • HOHiroaki Oishi
    Hiroaki Oishi
  • TSTokio Sanke
    Tokio Sanke
  • YNYasushi Nakamura
    Yasushi Nakamura
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Abstract
A rare case of mixed carcinoma of the ovary is reported, composed of a large cell neuroendocrine carcinoma and a mucinous borderline endocervical tumor. The large cell neuroendocrine carcinoma was composed of solid nests, sheets, and trabeculae of medium to large-sized cells, and was positive for synaptophysin. The mucinous epithelial tumor varied in appearance from a borderline to an intraepithelial carcinoma, and showed sparsely scattered immunoreactivity for chromogranin-A. Using an X-chromosome clonality assay, these 2 components showed patterns of monoclonality. These results suggest that the large cell neuroendocrine carcinoma may have arisen from the mucinous epithelial tumor.

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