Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease
Open Access
- 11 November 2019
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 116 (48) , 24326-24333
Abstract
Significance: Behaviors are realized through concerted activity in neural circuits. This activity results from a combination of neural connectivity and the properties of the involved neurons. By studying the activity of neurons in the human subthalamic nucleus during surgery for Parkinson’s disease, we report that these neurons have multiple stable states, and that brief electrical stimuli can lead to transitions between states. We thus suggest that these neurons function as finite state machines. The different states could influence the function of key motor circuits of the basal ganglia, and thus knowledge of these states in disease or in response to treatment could help to define new treatment strategies for people with movement disorders.Keywords
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