Prevention of obesity in Avy/a mice by dehydroepiandrosterone
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Abstract
Dehydroepiandrosterone, a mammalian glucose‐6‐phosphate dehydrogenase inhibitor, preventedAvy/a mice from becoming obese. Decreased accumulation of triacylglycerol accounted for a large portion of the weight difference between treated and controlAvy/a mice. Hepatic lipogenesis as measured by3H2O incorporation into total lipid was less in the dehydroepian drosterone‐treated mice. Dehydroepiandrosterone did not suppress appetite and had no apparent toxic effects at the doses used, and its weight controlling effects were reversible upon withdrawal of treatment.Keywords
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