Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus
Open Access
- 16 April 2021
- journal article
- research article
- Published by MDPI AG in Marine Drugs
- Vol. 19 (4) , 224
Abstract
Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray crystallography, Marfey’s method, and the ICD method. All isolates were tested for in vitro anti-food allergic bioactivities in immunoglobulin (Ig) E-mediated rat basophilic leukemia (RBL)-2H3 cells. Compound 13 significantly decreased the degranulation release with an IC50 value of 60.3 μM, compared to that of 91.6 μM of the positive control, loratadine.Keywords
Funding Information
- The National Natural Science Foundation of China (21877022, DY135-B2-08, 17GYY002NF02)
This publication has 44 references indexed in Scilit:
- Genetic, molecular, and biochemical basis of fungal tropolone biosynthesisProceedings of the National Academy of Sciences, 2012
- Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseumMarine Drugs, 2010
- On the structure of penipratynolene and WATetrahedron, 2010
- Cottoquinazoline A and Cotteslosins A and B, Metabolites from an Australian Marine-Derived Strain of Aspergillus versicolorJournal of Natural Products, 2009
- Brevicompanines A and B: new plant growth regulators produced by the fungus, Penicillium brevicompactumJournal of the Chemical Society, Perkin Transactions 1, 1998
- Diacetone-glucose architecture as a chirality template. Part 9.1 Enantioselective synthesis of (R)-mevalonolactone and (R)-[2H9]mevalonolactone on carbohydrate templateJournal of the Chemical Society, Perkin Transactions 1, 1997
- A new mevalonolactone glucoside derivative from the bark of Prunus buergeriana.Chemical and Pharmaceutical Bulletin, 1989
- Structures of fructigenines A and B, new alkaloids isolated from Penicillium fructigenum Takeuchi.Chemical and Pharmaceutical Bulletin, 1989
- Sequence dependence in the formation of pyroglutamyl peptides in solid phase peptide synthesisInternational Journal of Peptide and Protein Research, 1987
- Dehydrierung N‐sekundärer cyclischer Aminale und AcylaminaleArchiv der Pharmazie, 1976