From intermediate AMD to geographic atrophy: Biomarkers, endpoints, and a roadmap for next-generation clinical trials
Authors:
- Alessandro BerniABAlessandro Berni
- Philip J. RosenfeldPRPhilip J. Rosenfeld
- Daniela BacheriniDBDaniela Bacherini
- Usha ChakravarthyUCUsha Chakravarthy
- Varun ChaudaryVCVarun Chaudary
- Michele ReibaldiMRMichele Reibaldi
- Mengxi ShenMSMengxi Shen
- Daniel Shu Wei TingDTDaniel Shu Wei Ting
- Omer TrivizkiOTOmer Trivizki
- Pasquale ViggianoPVPasquale Viggiano
- Dinah ZurDZDinah Zur
- SriniVas SaddaSSSriniVas Sadda
Open Access
- 29 September 2026
- journal article
- Published by Elsevier in Progress in Retinal and Eye Research
- Vol. 115
Abstract
No abstract availableFunding Information
- Carl Zeiss Meditec AG
- Novartis
This publication has 233 references indexed in Scilit:
- Progression of Age-Related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5) or Chromosome 10 (ARMS2/HTRA1) or BothJAMA Ophthalmology, 2022
- Characterization of Drusen and Hyperreflective Foci as Biomarkers for Disease Progression in Age-Related Macular Degeneration Using Artificial Intelligence in Optical Coherence TomographyJAMA Ophthalmology, 2020
- Ten-Year Follow-up of Age-Related Macular Degeneration in the Age-Related Eye Disease StudyJAMA Ophthalmology, 2014
- Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular DegenerationJAMA, 2013
- Square Root Transformation of Geographic Atrophy Area Measurements to Eliminate Dependence of Growth Rates on Baseline Lesion Measurements: A Reanalysis of Age-Related Eye Disease Study Report No. 26JAMA Ophthalmology, 2013
- The Age-Related Eye Disease Study Severity Scale for Age-Related Macular DegenerationArchives of Ophthalmology (1950), 2005
- A Simplified Severity Scale for Age-Related Macular DegenerationArchives of Ophthalmology (1950), 2005
- Risk of Age-Related Macular Degeneration in Eyes With Macular Drusen or HyperpigmentationArchives of Ophthalmology (1950), 2003
- The Risk and Natural Course of Age-Related MaculopathyArchives of Ophthalmology (1950), 2003
- A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision LossArchives of Ophthalmology (1950), 2001