Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymesin vitro
Open Access
- 1 June 2001
- journal article
- research article
- Published by Taylor & Francis in Redox Report
- Vol. 6 (3) , 153-154
Abstract
To investigate the possible role of oxygen free radicals and oxidant stress in the toxic effects of phenoxyherbicides, we studied the in vitro effect of 4-chlorophenoxyacetic acid (4-CPA) on various human erythrocyte antioxidant enzymes, namely glucose-6-phosphate dehydrogenase, catalase, selenium-dependent glutathione peroxidase, glutathione reductase and Cu/Zn-superoxide dismutase. 4- CPA added in a dose of 1 ppm to human erythrocytes for 1 h caused a significant reduction in glucose-6- phosphate dehydrogenase (P P <0.001) activities, but did not significantly affect the activities of other enzymes. Such selective inactivation of specific erythrocyte antioxidant enzymes may play a role in the toxic effects of phenoxyherbicides.Keywords
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