Shaping postoperative outcomes: microbiota-modifying dietary fiber interventions in colorectal cancer treatment

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Abstract
The gut microbiota plays a key role in intestinal homeostasis by reinforcing the gut barrier and modulating inflammation. Gut barrier dysfunction or dysregulated inflammatory response in patients with colorectal cancer may lead to an increased risk of surgical complications associated with poor intestinal healing. Microbiota-modifying dietary interventions have the ability to shift microbial community structures and bacterial metabolite production, with profound implications for host health. This review focuses on the potential for short-term, preoperative, dietary fiber interventions in improving colorectal cancer surgical and oncological outcomes. Additionally, this review highlights important considerations for the optimization and personalization of dietary fiber interventions, notably individual- and fiber-specific microbiota responses.

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