Puqiedinone, a Novel 5α-Cevanine Alkaloid from the Bulbs of Fritillaria puqiensis, an Antitussive Traditional Chinese Medicine

Authors:
  • YHYee-Ping Ho
    Yee-Ping Ho
  • PLPing Li
    Ping Li
  • XLXiao-Gang Li
    Xiao-Gang Li
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Abstract
A novel 5 alpha-cevanine alkaloid, puqiedinone [1], was isolated from the bulbs of Fritillaria puqiensis, a traditional Chinese medicine used widely for its antitussive and expectorant properties. The structure of 1 was assigned as (20R,22S,25R)-20-deoxy-5 alpha-cevanine-3 beta-ol-6-one based on spectral analysis and comparison with the structures of related known compounds. Puqietinone [2] was also identified from the same herbal plant and the structure was revised as (22R,25S)-N-methyl-22,26-epiminocholest-3 beta-ol-6-one based on spectroscopic and X-ray crystallographic methods.