A Study of the Mechanism of the Toluidine Blue Dye Test

Authors:
  • PHP. Herlin
    P. Herlin
  • JMJ. Marnay
    J. Marnay
  • JJJ. H. Jacob
    J. H. Jacob
  • JOJ. M. Ollivier
    J. M. Ollivier
  • AMA. M. Mandard
    A. M. Mandard
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Abstract
Toluidine blue is commonly used by endoscopists as a screening test for squamous cell carcinoma. Little information is available on the mechanism of vital staining as it is not preserved by conventional fixation. By using a simple method to stabilize toluidine blue, the authors were able to study the action of the dye under the light and electron microscope. The findings are reported.