Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs
Authors:
- Stavros C. ManolagasSMStavros C. Manolagas
- Teresita BellidoTBTeresita Bellido
Abstract
No abstract availableKeywords
This publication has 41 references indexed in Scilit:
- From Molds and Macrophages to Mevalonate: A Decade of Progress in Understanding the Molecular Mode of Action of BisphosphonatesCalcified Tissue International, 2004
- Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugsThe American Journal of Medicine, 2002
- Transduction of Cell Survival Signals by Connexin-43 HemichannelsJournal of Biological Chemistry, 2002
- Cellular and molecular mechanisms of action of bisphosphonatesCancer, 2000
- Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitoninJournal of Clinical Investigation, 1999
- Cyclic Administration of Pamidronate in Children with Severe Osteogenesis ImperfectaNew England Journal of Medicine, 1998
- Alendronate for the Prevention and Treatment of Glucocorticoid-Induced OsteoporosisNew England Journal of Medicine, 1998
- Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including RasJournal of Bone and Mineral Research, 1998
- Dissociation of binding and antiresorptive properties of hydroxybisphosphonates by substitution of the hydroxyl with an amino groupJournal of Bone and Mineral Research, 1996
- Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivoJournal of Bone and Mineral Research, 1995