Detection of Pathologic Prion Protein in the Olfactory Epithelium in Sporadic Creutzfeldt–Jakob Disease
Authors:
- Gianluigi ZanussoGZGianluigi Zanusso
- Sergio FerrariSFSergio Ferrari
- Franco CardoneFCFranco Cardone
- Paolo ZampieriPZPaolo Zampieri
- Matteo GelatiMGMatteo Gelati
- Michele FioriniMFMichele Fiorini
- Alessia FarinazzoAFAlessia Farinazzo
- Marina GardimanMGMarina Gardiman
- Tiziana CavallaroTCTiziana Cavallaro
- Marina BentivoglioMBMarina Bentivoglio
- Pier Giorgio RighettiPRPier Giorgio Righetti
- Maurizio PocchiariMPMaurizio Pocchiari
Open Access
- 20 February 2003
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 348 (8) , 711-719
Abstract
Olfactory cortexes and the olfactory tracts are involved in sporadic Creutzfeldt–Jakob disease. We examined peripheral regions of the olfactory sensory pathway, including the olfactory mucosa, to assess whether pathologic infectious prion protein (PrPSc) is deposited in the epithelium lining the nasal cavity.Keywords
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