One hundred years of Drosophila cancer research: no longer in solitude
Open Access
- 1 April 2019
- journal article
- research article
- Published by The Company of Biologists in Disease Models & Mechanisms
- Vol. 12 (4)
Abstract
When Mary Stark first described the presence of tumours in the fruit fly Drosophila melanogaster in 1918, would she ever have imagined that flies would become an invaluable organism for modelling and understanding oncogenesis? And if so, would she have expected it to take 100 years for this model to be fully accredited? This Special Article summarises the efforts and achievements of Drosophilists to establish the fly as a valid model in cancer research through different scientific periods.Keywords
Funding Information
- Ministerio de Economía y Competitividad (BFU2015-64239-R)
- Agencia Estatal de Investigación (SEV-2013-0317)
- Fundación Científica Asociación Española Contra el Cáncer
This publication has 87 references indexed in Scilit:
- Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epitheliaProceedings of the National Academy of Sciences, 2012
- Drosophila as a Tool for Personalized Medicine: A PrimerPersonalized Medicine, 2010
- Interaction between RasV12 and scribbled clones induces tumour growth and invasionNature, 2010
- dMyc Transforms Cells into Super-CompetitorsCell, 2004
- Drosophila Myc Regulates Organ Size by Inducing Cell CompetitionCell, 2004
- Initial sequencing and analysis of the human genomeNature, 2001
- The Genome Sequence of Drosophila melanogasterScience, 2000
- The FLP recombinase of yeast catalyzes site-specific recombination in the drosophila genomeCell, 1989
- Mutations affecting segment number and polarity in DrosophilaNature, 1980
- Minutes: Mutants of Drosophila autonomously affecting cell division rateDevelopmental Biology, 1975