Presence of anti‐kinectin and anti‐PMS1 antibodies in Japanese aplastic anaemia patients
Authors:
Open Access
- 9 December 2004
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 128 (2) , 221-223
Abstract
While anti-kinectin antibodies are frequently found in aplastic anaemia (AA) patients from the US (39%), we detected antibodies in only three of 30 (10%) of Japanese AA cases. Additionally, population differences in anti-postmeiotic segregation increased 1 (PMS1) responses were seen, with detectable antibody in 10% Japanese and 0% US AA patients. In one of the Japanese AA patients with detectible anti-kinectin antibodies, the autoantibody disappeared coincidentally with the partial resolution of pancytopenia. These results support the hypothesis that the epidemiology of AA is heterogeneous and suggest that anti-kinectin autoantibody titre may serve as a surrogate maker for the disease activity of AA.Keywords
This publication has 7 references indexed in Scilit:
- Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cellsBlood, 2004
- Autoantibodies frequently detected in patients with aplastic anemiaBlood, 2003
- Acquired Aplastic AnemiaAnnals of Internal Medicine, 2002
- Aplastic anemia in the orientInternational Journal of Hematology, 2002
- The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2Nucleic Acids Research, 2001
- Molecular Cloning of the Human Glucose‐Regulated Protein ERp57/GRP58, a Thiol‐Dependent ReductaseEuropean Journal of Biochemistry, 1995
- Kinectin, a major kinesin-binding protein on ER.Journal of Cell Biology, 1992