Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection
Open Access
- 16 February 2023
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 67 (2) , e0145922
Abstract
The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro . Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil and avibactam ARX-1796 showed efficacy in a mouse model of M. abscessus lung infection.Keywords
Funding Information
- HHS | National Institutes of Health (R01AI132374)
This publication has 31 references indexed in Scilit:
- Mycobacterium abscessus and β-Lactams: Emerging Insights and Potential OpportunitiesFrontiers in Microbiology, 2018
- Teicoplanin – Tigecycline Combination Shows Synergy Against Mycobacterium abscessusFrontiers in Microbiology, 2018
- Mycobacterium abscessus l , d -Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not PenicillinsAntimicrobial Agents and Chemotherapy, 2017
- Combinations of Avibactam and Carbapenems Exhibit Enhanced Potencies Against Drug-Resistant Mycobacterium AbscessusFuture Microbiology, 2017
- Comparing the harmful effects of nontuberculous mycobacteria and Gram negative bacteria on lung function in patients with cystic fibrosisJournal of Cystic Fibrosis, 2016
- β-Lactamase inhibition by avibactam in Mycobacterium abscessusJournal of Antimicrobial Chemotherapy, 2014
- In vitro activity of cefoxitin and imipenem against Mycobacterium abscessus complexClinical Microbiology and Infection, 2014
- Shifting paradigms of nontuberculous mycobacteria in cystic fibrosisRespiratory Research, 2014
- Syntheses and Pharmacokinetic Studies of Prodrug Esters for the Development of Oral Carbapenem, L-084The Journal of Antibiotics, 2006
- Terminology relating to methods for the determination of susceptibility of bacteria to antimicrobial agentsClinical Microbiology and Infection, 2000