The Effects of Combination of Marbofloxacin and Ceftiofur on Serum Biochemistry in Lambs with Respiratory System Infection

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Abstract
In this study, the aim was to determine the effect of combination of marbofloxacin and ceftiofur on serum biochemical parameters in lambs with clinical respiratory system infection. The study included 10 Merino lambs showing symptoms of respiratory system infection in a commercial farm. Blood samples were taken from the animals before drug administration (hour 0) and 24, 48, 72, 96, and 120 hours after the first simultaneous combined drug administration (marbofloxacin 2 mg/kg, IM, once a day + ceftiofur 1 mg/kg, IM, once a day; 5 days). Serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine levels were measured in the autoanalyzer from the serum obtained from the samples taken, and the clinical symptoms of the animals were monitored daily. At the final sampling time (120 hours), AST, ALT, and BUN levels were found to be significantly higher (P < 0.05) compared to those at the initial sampling time (hour 0). On the second day of treatment, clinical signs (runny nose, fever, cough, etc.) and feed consumption began to improve. The combined use of ceftiofur and marbofloxacin is highly effective in the treatment of severe respiratory system infection in lambs.

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