Exploring the Link Between Noncoding RNAs and Glycolysis in Colorectal Cancer
Open Access
- 24 February 2025
- journal article
- review article
- Published by Wiley in Journal of Cellular and Molecular Medicine
- Vol. 29 (4) , e70443
Abstract
Glycolysis is implicated in the onset and progression of colorectal cancer (CRC) through its influence on the proliferation, invasiveness, chemoresistance and immune system evasion of neoplasm cells. Increasing evidence has shown that the abnormal expression of noncoding RNAs (ncRNAs), especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), in CRC is closely related to glycolysis. In this review, we present a synthesis of the latest research insights into the modulatory roles and distinct pathways of ncRNAs in the glycolytic process in CRC. This knowledge may pave the way for identifying novel therapeutic targets, as well as novel prognostic and diagnostic biomarkers for CRC.Keywords
This publication has 127 references indexed in Scilit:
- HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protectionAutophagy, 2015
- MicroRNA-135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancersOncology Reports, 2014
- The structure, function and evolution of proteins that bind DNA and RNANature Reviews Molecular Cell Biology, 2014
- High‐resolution crystal structures of the photoreceptor glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) with three and four‐bound NAD moleculesProtein Science, 2014
- Overexpression of MicroRNA-122 Re-sensitizes 5-FU-Resistant Colon Cancer Cells to 5-FU Through the Inhibition of PKM2 In Vitro and In VivoCell Biochemistry and Biophysics, 2014
- miR‐181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathwayFEBS Letters, 2014
- Capillary electrophoresis-based assay of phosphofructokinase-1Analytical Biochemistry, 2014
- Tumor glycolysis as a target for cancer therapy: progress and prospectsMolecular Cancer, 2013
- miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effectOncology Reports, 2012
- Small peptides released from muscle glycolytic enzymes during dry-cured ham processingJournal of Proteomics, 2011