Interaction of clozapine with the histamine H3 receptor in rat brain
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Open Access
- 1 April 1995
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 114 (8) , 1523-1524
Abstract
We examined possible interactions between neuroleptics and the histamine H3 receptor and found an interaction of clozapine with this receptor. In competition binding experiments, using the H3 antagonist, [125I]‐iodophenpropit, we observed a Ki of 236 ± 87 nM. Functionally, clozapine was studied on the H3‐mediated inhibition of [3H]‐5‐hydroxytryptamine ([3H]‐5‐HT) release from rat brain cortex slices. Clozapine acts as an antagonist with an apparent KB value of 79.5 nM.Keywords
This publication has 9 references indexed in Scilit:
- Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and ratings of symptomsSchizophrenia Research, 1995
- Characterization of the binding of the first selective radiolabeled histamine H3‐receptor antagonist, [125I]‐iodophenpropit, to rat brainBritish Journal of Pharmacology, 1994
- Famotidine adjunctive pharmacotherapy for schizophrenia: preliminary data.1993
- Tissue Concentrations of Clozapine and its Metabolites in the RatNeuropsychopharmacology, 1993
- Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophreniaBiological Psychiatry, 1991
- ClozapineNew England Journal of Medicine, 1991
- Involvement of presynaptic H3 receptors in the inhibitory effect of histamine on serotonin release in the rat brain cortexNaunyn-Schmiedeberg's Archives of Pharmacology, 1990
- Effect of famotidine on deficit symptoms of schizophreniaThe Lancet, 1990
- HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulationEuropean Journal of Pharmacology, 1987