Addressing Protein–Protein Interactions with Small Molecules: A Pro‐Pro Dipeptide Mimic with a PPII Helix Conformation as a Module for the Synthesis of PRD‐Binding Ligands
Authors:
- Peter HuyPHPeter Huy
- Robert OpitzRORobert Opitz
- Cédric ReuterCRCédric Reuter
- Christian FreundCFChristian Freund
- Matthias MüllerMMMatthias Müller
- Hartmut OschkinatHOHartmut Oschkinat
- Hans‐Günther SchmalzHSHans‐Günther Schmalz
- 27 August 2010
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 49 (39) , 7111-7115
Abstract
No abstract availableKeywords
This publication has 46 references indexed in Scilit:
- Proline-rich Sequence RecognitionMolecular & Cellular Proteomics, 2009
- Binding Mechanism of an SH3 Domain Studied by NMR and ITCJournal of the American Chemical Society, 2009
- Molecular Building Kit of Fused-Proline-Derived Peptide Mimetics Allowing Specific Adjustment of the Dihedral Ψ AngleThe Journal of Organic Chemistry, 2007
- Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transductionBiochemical Journal, 2005
- Cell Penetrating Agents Based on a Polyproline Helix ScaffoldJournal of the American Chemical Society, 2005
- Recognition of Proline‐Rich Motifs by Protein–Protein‐Interaction DomainsAngewandte Chemie International Edition, 2005
- Erkennung Prolin‐reicher Motive (PRMs) durch Protein‐Protein‐WechselwirkungsdomänenAngewandte Chemie, 2005
- Thermodynamic Dissection of the Binding Energetics of Proline-rich Peptides to the Abl-SH3 Domain: Implications for Rational Ligand DesignJournal of Molecular Biology, 2004
- Exploring the Leucine-Proline Binding Pocket of the Src SH3 Domain Using Structure-Based, Split-Pool Synthesis and Affinity-Based SelectionJournal of the American Chemical Society, 1998
- Critical chain length for polyproline‐II structure formation in H‐Gly‐(Pro)n‐OHInternational Journal of Peptide and Protein Research, 1982