Subsecond dopamine fluctuations do not specify the vigor of ongoing actions
Open Access
- 10 November 2025
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 28 (12) , 2432-2438
Abstract
Dopamine (DA) is essential for the production of vigorous actions, but how DA modifies the gain of motor commands remains unclear. Here we show that subsecond DA transients in the striatum of mice are neither required nor sufficient for specifying the vigor of ongoing forelimb movements. Our findings have important implications for our understanding of how DA contributes to motor control under physiological conditions and in Parkinson’s disease.Keywords
Funding Information
- U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH130658)
- U.S. Department of Health & Human Services | NIH | NIH Office of the Director (DP2NS105553)
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R21NS133640)
- Dana Foundation
- Whitehall Foundation
- Parkinson's Foundation
- Canada First Research Excellence Fund (HBHL)
- Santé (365987)
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