Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor
- 5 June 2015
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 112 (24) , 7599-7604
Abstract
Significance: In highly socialized animals such as humans or songbirds, individuals postnatally develop their skills to communicate with conspecifics under the social influence. Both genetic and environmental influences play a crucial role in the development of such abilities, but dissection of the influences has been difficult, because genetic manipulation of avian species is still a challenging issue. In this study, we applied transgenic technology to songbirds along with an experimental song-training paradigm to separately manipulate both genes and social environment, and found that appropriate activity of cAMP response element-binding protein (CREB) is necessary for the postnatal song learning in songbirds.Keywords
Funding Information
- Japan Science and Technology Agency (PRESTO)
- Japan Society for the Promotion of Science (22700335)
- Ministry of Education, Culture, Sports, Science, and Technology (25115717)
- Japan Society for the Promotion of Science (24220009)
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