Risk Factors Associated With Incident Cerebral Microbleeds According to Location in Older People

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Abstract
Cerebral microbleeds (CMBs), visualized as hypointense lesions on T2-weighted gradient-echo magnetic resonance imaging (MRI), frequently occur in healthy older people.1,2 Cerebral microbleeds are an asymptomatic precursor of intracerebral hemorrhage (ICH),3,4 and their presence is associated with an increased risk for (recurrent) ischemic stroke,5 cognitive impairment,6 and mortality.7 In histopathologic studies, CMBs represent hemosiderin deposits from microvascular leakage.8 Similar to ICH, the pathophysiologic features of CMBs may differ according to their location, with lobar (cortical-subcortical) CMBs attributable to cerebral amyloid angiopathy and deep (basal ganglia, thalamus, and brainstem) CMBs attributable to hypertensive vasculopathy.3

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