Estrogen receptor signaling markers are poor predictors of muscle hypertrophy outcomes in young women and men
- 1 February 2026
- journal article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 140 (2) , 339-350
Abstract
This is the first study to evaluate acute and chronic resistance training-induced changes in skeletal muscle estrogen receptor alpha (ERα) signaling and satellite cell (SC) dynamics in women and men. Although ERα content differed between sexes and SC increased with training, ERα markers were not consistently linked to muscle hypertrophy, particularly in women. These findings challenge the presumed role of ERα in hypertrophic adaptation and provide new insights into sex-specific mechanisms of muscle remodeling.Keywords
Funding Information
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2023/04739-2)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2024/12893-4)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (311387/2021-7)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (140107/2023-1)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (407748/2025-3)
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