A Stereospecific Cyclization Catalyzed by an Antibody

Authors:
Publisher website
Google Scholar
Abstract
A monoclonal antibody elicited by a transition-state analog that is representative of an intramolecular six-membered ring cyclization reaction acted as a stereospecific, enzyme-like catalyst for the appropriate substrate. Formation of a single enantiomer of a δ-lactone from the corresponding racemic δ-hydroxyester was accelerated by the antibody by about a factor of 170, which permitted isolation of the lactone in an enantiomeric excess of about 94 percent. This finding demonstrates the feasibility of catalytic-antibody generation for chemical transformations that require stereochemical control.

This publication has 10 references indexed in Scilit: