Senescence and Aging: Does It Impact Cancer Immunotherapies?
Open Access
Abstract
Cancer incidence increases drastically with age. Of the many possible reasons for this, there is the accumulation of senescent cells in tissues and the loss of function and proliferation potential of immune cells, often referred to as immuno-senescence. Immune checkpoint inhibitors (ICI), by invigorating immune cells, have the potential to be a game-changers in the treatment of cancer. Yet, the variability in the efficacy of ICI across patients and cancer types suggests that several factors influence the success of such inhibitors. There is currently a lack of clinical studies measuring the impact of aging and senescence on ICI-based therapies. Here, we review how cellular senescence and aging, either by directly altering the immune system fitness or indirectly through the modification of the tumor environment, may influence the cancer-immune response.Keywords
This publication has 166 references indexed in Scilit:
- Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activationNature Cell Biology, 2012
- Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with ageProceedings of the National Academy of Sciences, 2011
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disordersNature, 2011
- Therapy-Induced Senescence in CancerJNCI: Journal of the National Cancer Institute, 2010
- Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune statusAging Cell, 2010
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent MannerCancer Cell, 2010
- Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human agingAging Cell, 2009
- Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapyCancer Immunology, Immunotherapy, 2008
- Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virusJournal of Experimental Medicine, 2008
- Neutrophil Extracellular Traps Kill BacteriaScience, 2004