Anti-inflammatory Labdane Diterpenoids from Lagopsis supina
- 8 April 2014
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 77 (4) , 1047-1053
Abstract
Ten new labdane diterpenoids, lagopsins A–H (1–3, 5, 7–10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane diterpenoids (11–15), were isolated from the whole plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 7, 9, 13, and 15 exhibited moderate inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range 14.9–34.9 μM.Keywords
This publication has 18 references indexed in Scilit:
- Antimycobacterial Labdane Diterpenes fromLeucas stelligeraJournal of Natural Products, 2013
- Labdane Diterpenoids from Leonotis leonurusPhytochemistry, 2013
- Bis-spirolabdane Diterpenoids from Leonotis nepetaefoliaJournal of Natural Products, 2012
- Labdane Diterpenoids from Leonurus sibiricusJournal of Natural Products, 2011
- Bis-spirolabdane-Type Diterpenoids from Leonurus sibiricusJournal of Natural Products, 2010
- Synthesis of sibiricinone A, sibiricinone B and leoheterinTetrahedron, 2008
- New Bis-spirolabdane-Type Diterpenoids from Leonurus heterophyllus SW.Chemical and Pharmaceutical Bulletin, 2005
- New Labdane-Type Diterpenoids from Leonurus heterophyllus SW.Chemical and Pharmaceutical Bulletin, 2005
- Labdane Diterpenes of Leonurus sibiricusJournal of Natural Products, 2004
- Preleoheterin and leoheterin, two labdane diterpenes from Leonurus heterophyllusPhytochemistry, 1993