A convenient synthesis for some new pyrido[3′,2′:4,5]thieno‐[3,2‐d]pyrimidine derivatives with potential biological activity
Authors:
- 1 December 1992
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 29 (7) , 1693-1702
Abstract
Ready, convenient synthesis for 8‐cyano‐7‐ethoxy‐4‐oxo‐9‐phenyl‐2‐substituted‐1,2,3,‐4‐tetrahydropyrido‐[3′,2′:,4,5]thieno[3,2‐d]pyrimidines 5, 8‐cyano‐7‐ethoxy‐4‐oxo‐9‐phenyl‐2‐substituted‐3,4‐dihydropyrido[3′,2‐: 4,5]thieno[3,2‐d]pyrimidines 6, 4‐chloro‐8‐cyano‐7‐ethoxy‐9‐phenyl‐2‐substitutedpyrido[3′,2′:4,5]thieno[3,2‐4 ‐pyrimidines 7 and 8‐cyano‐7‐ethoxy‐2‐(2′‐nitrophenyl)‐9‐phenyl‐4‐substitutedpyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidines 8‐18 from 2‐chloro‐3,5‐dicyano‐6‐ethoxy‐4‐phenylpyridine 1 via 3,5‐dicyano‐6‐ethoxy‐2‐mercapto‐4‐phenylpyridine 2 and aminocarboxamide 4 are reported. In addition, the reaction of hydrazino derivative 12 with reagents such as formic acid and triethyl orthoformate yielded the fused tetraheterocyclic 8‐cyano‐9‐ ethoxy‐5‐(2′‐nitrophenyl)‐ 7‐phenylpyrido[3′,2′:4,5]thieno[2,3‐e]‐1, 2,4‐triazolo[4,3‐c]pyrimidine system 19.Keywords
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