In vitro assessment of apheresis and pooled buffy coat platelet components suspended in plasma and SSP+ photochemically treated with amotosalen and UVA for pathogen inactivation (INTERCEPT Blood System™)

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Abstract
Background and Objectives  INTERCEPT Blood System™ is a pathogen inactivation system for blood components. The initial approval required a platelet component to be suspended in a combination of plasma and Platelet additive Solution/PAS‐III. Improved platelet storage has been reported with Mg++ and K+ supplementation (PAS‐IIIM). This study validated the use of INTERCEPT™/PAS‐IIIM for apheresis and pooled buffy‐coat platelet components.Materials and Methods  The platelet dose and pH throughout 5 days of storage met the European and French requirements for quality standards.Results and Conclusion  Additional metabolic and activation assessments of the treated platelets confirmed the previously reported superiority of PAS‐IIIM over PAS‐III, but extended it to the INTERCEPT™ process.

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