A Single Phosphine Ligand Allows Palladium‐Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols
Open Access
- 12 September 2011
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 50 (42) , 9943-9947
Abstract
Forging a bond: An efficient, general palladium catalyst for CO bond‐forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron‐rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands.Keywords
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