Skeletal Uptake of99mTc-Diphosphonate in Relation to Local Bone Blood Flow

Authors:
  • BSBarry A. Siegel
    Barry A. Siegel
  • RDRichard L. Donovan
    Richard L. Donovan
  • PAPhilip O. Alderson
    Philip O. Alderson
  • GMGregory R. Mack
    Gregory R. Mack
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Abstract
The right/left ratios of tibial uptake of 99mTc-diphosphonate (EHDP) and relative blood flow (based on microsphere distribution) were determined in control rats and rats with a ligated right femoral artery or a healing right tibial fracture. Correlation between 99mTc-EHDP uptake and relative blood flow was highly significant (r=0.917; P less than 0.0001) for relative flow ratios less than 1.7. When the ratio was greater than 1.7, there was little further increase in 99mTc-EHDP uptake. Ligation of the femoral artery in rats with healing fractures resulted in a more marked reduction of blood flow than of 99mTc-EHDP uptake. These results suggest that regional bone blood flow is a major determinant of 99mTc-EHDP uptake, though changes in regional tracer extraction efficiency are also important.