Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients
Authors:
- Marco GuarneriMGMarco Guarneri
- Calogero GeraciCGCalogero Geraci
- Francesca IncalcaterraFIFrancesca Incalcaterra
- Rosalia ArsenaRARosalia Arsena
- Giuseppe MulèGiuseppe Mulè
- Francesco VaccaroFVFrancesco Vaccaro
- Clelia LunaCLClelia Luna
- Giovanni CerasolaGCGiovanni Cerasola
- Santina CottoneSCSantina Cottone
- 13 September 2012
- journal article
- Published by Springer Nature in Hypertension Research
- Vol. 36 (2) , 129-133
Abstract
The intima-media thickness (IMT) is considered as a surrogate marker for atherosclerotic disease. The aim of this study was to analyze the relationship of carotid IMT with fetuin-A in patients with essential hypertension (EH) and normal renal function. The plasma levels of fetuin-A, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and the biomarker of oxidative stress 8-iso-PGF2alpha were assayed in samples from 105 untreated EH patients. Carotid IMT measurements were also performed. EH was studied overall and after dividing in EH with IMT ≥ and 0.9 mm (AUC (area under the curve) 0.738, P<0.0001). Our results suggest that in EH, fetuin-A is associated with the IMT independently of oxidative stress and renal function, thus predicting increases in the IMT.Keywords
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