Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes—A novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies
- 22 April 2010
- journal article
- Published by Elsevier in International Immunopharmacology
- Vol. 10 (7) , 784-790
Abstract
No abstract availableKeywords
This publication has 24 references indexed in Scilit:
- Achieving the Ultimate Physiological Goal in Transition State Analogue Inhibitors for Purine Nucleoside PhosphorylaseJournal of Biological Chemistry, 2003
- Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777International Immunopharmacology, 2002
- Apoptosis and its modulation during B lymphopoiesis in mouse bone marrowImmunological Reviews, 2000
- dNTP pools imbalance as a signal to initiate apoptosisCellular and Molecular Life Sciences, 1996
- PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. II. Effects on nucleoside catabolism in human and rat bloodin vitroInflammation Research, 1993
- Different pathways for deoxyguanosine toxicity in T-lymphocytes of various developmental stagesInternational Journal of Immunopharmacology, 1988
- Central nervous system dysfunction and erythrocyte guanosine triphosphate depletion in purine nucleoside phosphorylase deficiency.Archives of Disease in Childhood, 1987
- Toxicity of naturally occuring purine deoxyribonucleosidesPharmacology & Therapeutics, 1980
- An abnormal form of purine nucleoside phosphorylase in a family with a child with severe defective T-cell-and normal B-cell immunityClinica Chimica Acta, 1976
- NUCLEOSIDE-PHOSPHORYLASE DEFICIENCY IN A CHILD WITH SEVERELY DEFECTIVE T-CELL IMMUNITY AND NORMAL B-CELL IMMUNITYThe Lancet, 1975