Validation of Insulin Sensitivity and Secretion Indices Derived from the Liquid Meal Tolerance Test

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Abstract
Background: A liquid meal tolerance test (LMTT) has been proposed as a useful alternative to more labor-intensive methods of assessing insulin sensitivity and secretion. Objective: This substudy, conducted at the conclusion of a randomized, double-blind crossover trial, compared insulin sensitivity indices from a LMTT (Matsuda insulin sensitivity index [MISI] and LMTT disposition index [LMTT-DI]) with indices derived from minimal model analysis of results from the insulin-modified intravenous glucose tolerance test (IVGTT) (insulin sensitivity index [S I ] and disposition index [DI]). Results: Participants included men ( n = 16) and women ( n = 8) without diabetes but with increased abdominal adiposity (waist circumference ≥102 cm and ≥89 cm, respectively) and mean age of 48.9 years. The correlation between S I and the MISI was 0.776 ( P < 0.0001). The respective associations between S I and MISI with waist circumference ( r = −0.445 and −0.554, both P < 0.05) and body mass index were similar ( r = −0.500 and −0.539, P < 0.05). The correlation between DI and LMTT-DI was 0.604 ( P = 0.002). Conclusions: These results indicate that indices of insulin sensitivity and secretion derived from the LMTT correlate well with those from the insulin-modified IVGTT with minimal model analysis, suggesting that they may be useful for application in clinical and population studies of glucose homeostasis.

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