Effects of ipragliflozin on the development and progression of kidney disease in patients with type 2 diabetes: An analysis from a multicenter prospective intervention study

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Abstract
Aims/Introduction Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. Methods This was an investigator-initiated multicenter prospective intervention study in which ipragliflozin (50 mg) was administered once daily, and glycemic control, estimated glomerular filtration rate (eGFR) and adverse events were evaluated until 104 weeks after starting research. Results There were 407 patients analyzed. In the eGFR >= 90 group and eGFR >= 60 to = 45 to = 60). In patients with low eGFR (eGFR >= 30 to <60), ipragliflozin has the possibility of increasing eGFR and exerting a renoprotective effect.

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