AlCl 3 /Cyclohexane Mediated Electrophilic Activation of Isothiocyanates: An Efficient Synthesis of Thioamides
- 9 August 2016
- journal article
- research article
- Published by Wiley in ChemistrySelect
- Vol. 1 (12) , 3228-3231
Abstract
An efficient protocol was developed for the Friedel Crafts type thioarylation for the synthesis of aromatic/heteroaromaticthioamide derivatives from aryl isothiocyanates and electron rich aromatic/heteroaromatic molecules by employing the Lewis acid AlCl 3 and the less hazardous solvent cyclohexane at 70°C. The developed protocol offers advantages over the previous methods such as use of stoichiometric amount of reactants/reagent, less toxic solvent, shorter reaction time and higher yields.Keywords
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