Metabolic influences on RNA biology and translation
Authors:
- 17 January 2017
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Biochemistry and Molecular Biology
- Vol. 52 (2) , 176-184
Abstract
Protein translation is one of the most energetically demanding processes for a cell to undertake. Changes in the nutrient environment may result in conditions that cannot support the rates of translation required for cell proliferation. As such, a cell must monitor its metabolic state to determine which mRNAs to translate into protein. How the various RNA species that participate in translation might relay information about metabolic state to regulate this process is not well understood. In this review, we discuss emerging examples of the influence of metabolism on aspects of RNA biology. We discuss how metabolic state impacts the localization and fate of different RNA species, as well as how nutrient cues can impact post-transcriptional modifications of RNA to regulate their functions in the control of translation.Keywords
Funding Information
- National Institute of General Medical Sciences (R01GM094314)
This publication has 75 references indexed in Scilit:
- Reconsidering Movement of Eukaryotic mRNAs between Polysomes and P BodiesMolecular Cell, 2011
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTONature Chemical Biology, 2011
- Converting nonsense codons into sense codons by targeted pseudouridylationNature, 2011
- Cellular Dynamics of RNA ModificationAccounts of Chemical Research, 2011
- Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth GenesMolecular Cell, 2011
- Eukaryotic Stress Granules: The Ins and Outs of TranslationMolecular Cell, 2009
- Molecular mechanisms of mTOR-mediated translational controlNature Reviews Molecular Cell Biology, 2009
- Rapid and Reversible Nuclear Accumulation of Cytoplasmic tRNA in Response to Nutrient AvailabilityMolecular Biology of the Cell, 2007
- RNA regulons: coordination of post-transcriptional eventsNature Reviews Genetics, 2007
- Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsProceedings of the National Academy of Sciences, 2004