Sjogren's syndrome: a potential new aetiology of mild cobalamin deficiency

Authors:
  • EAE. Andres
    E. Andres
  • BGB. Goichot
    B. Goichot
  • APA.‐E. Perrin
    A.‐E. Perrin
  • SVS. Vinzio
    S. Vinzio
  • CDC. Demangeat
    C. Demangeat
  • JSJ.‐L. Schlienger
    J.‐L. Schlienger
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Abstract
Sir, Malabsorption of cobalamin from the food [FCM (food cobalamin malabsorption)] is one of the leading causes of cobalamin deficiency [1]. The scientific basis of FCM is the inability to isolate cobalamin from food or from its binders (particularly haptocorrin) without acid or pepsin [2]. Various conditions or disorders may be associated with FCM, mainly atrophic gastritis and partial gastric surgery [2]. In recent years, several other conditions or agents have been identified: stomach stapling (for obesity), acid‐suppressive drugs (H2 antagonists, proton pump inhibitors) [3] and Helicobacter pylori infection [4]. In this letter, we report a new aetiology of FCM: Sjögren's syndrome.