A Facile Access to Aryl α-Sialosides: the Combination of a Volatile Amine Base and Acetonitrile in Glycosidation of Sialosyl Chlorides

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Abstract
We have succeeded in achieving a facile access to 4-nitrophenyl and 4-methylumbelliferyl-α-sialosides. To sialosyl chlorides which are fully protected with acetyl groups as glycosyl donors, the action of phenols with diisopropylethylamine in acetonitrile brought about high yield as well as facile product isolation.