Progress and limitations of oral peptide delivery as a potentially transformative therapy
- 1 February 2022
- journal article
- research article
- Published by Taylor & Francis in Expert Opinion on Drug Delivery
- Vol. 19 (2) , 163-178
Abstract
The oral delivery of peptides offers advantages over the injectable route of administration due to patient convenience. However, oral delivery remains challenging due to physiological barriers. Num...Keywords
This publication has 80 references indexed in Scilit:
- Future directions for peptide therapeutics developmentDrug Discovery Today, 2013
- The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivoBiomaterials, 2011
- Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancerInternational Journal of Pharmaceutics, 2009
- Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon CalcitoninBMC Clinical Pharmacology, 2008
- A new concept in colonic drug targeting: a combined pH‐responsive and bacterially‐triggered drug delivery technologyAlimentary Pharmacology & Therapeutics, 2008
- Enhancement of intestinal absorption of poorly absorbed hydrophilic compounds by simultaneous use of mucolytic agent and non-ionic surfactantEuropean Journal of Pharmaceutics and Biopharmaceutics, 2006
- Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile saltsJournal of Controlled Release, 2005
- The effect of ΔG on the transport and oral absorption of macromoleculesJournal of Pharmaceutical Sciences, 2004
- Absorption Enhancing Effect of Labrasol on the Intestinal Absorption of Insulin in RatsJournal of Drug Targeting, 2002
- Site-Dependent Effect of Aprotinin, Sodium Caprate, Na2EDTA and Sodium Glycocholate on Intestinal Absorption of Insulin.Biological and Pharmaceutical Bulletin, 1993