Sodium N‐Methyl‐D‐glucamine Dithiocarbamate and Cadmium Intoxication

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Abstract
The sodium and ammonium salts of N‐methyl‐D‐glucamine dithiocarbamate were prepared and their usefulness as antidotes for cadmium intoxication investigated. This chelating agent was found to be effective in both acute and repeated exposure cadmium poisoning. A single intraperitoneal injection of sodium N‐methyl‐D‐glucamine dithiocarbamate (NaNMG‐DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal (>95%) dose of cadmium chloride (10 mg CdCl2/kg body weight) and results in a subsequent dose‐dependent decrease in the liver and kidney burdens of cadmium ion. In repeated exposure cadmium intoxication, repeated administration of NaNMG‐DTC can result in substantial reductions in both the kidney (71%) and the liver (40%) levels of cadmium. The LD50 of the compound was not determined, but single injections of 26.6 mmol/kg body weight (injectate volume 1.0 ml) are well tolerated in mice.