Modelling Particle Agglomeration on through Elastic Valves under Flow
Open Access
- 26 July 2021
- journal article
- research article
- Published by MDPI AG in Chemengineering
- Vol. 5 (3) , 40
Abstract
This work proposes a model of particle agglomeration in elastic valves replicating the geometry and the fluid dynamics of a venous valve. The fluid dynamics is simulated with Smooth Particle Hydrodynamics, the elastic leaflets of the valve with the Lattice Spring Model, while agglomeration is modelled with a 4-2 Lennard-Jones potential. All the models are combined together within a single Discrete Multiphysics framework. The results show that particle agglomeration occurs near the leaflets, supporting the hypothesis, proposed in previous experimental work, that clot formation in deep venous thrombosis is driven by the fluid dynamics in the valve.Keywords
Funding Information
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/S001360/1)
- British Heart Foundation (FS/18/68/34226)
This publication has 39 references indexed in Scilit:
- Venous Valvular Stasis–Associated Hypoxia and Thrombosis: What Is the Link?Annual Review of Physiology, 2011
- Thromboprophylaxis in the intensive care unit: Focus on medical–surgical patientsCritical Care Medicine, 2010
- Visualization and analysis of atomistic simulation data with OVITO–the Open Visualization ToolModelling and Simulation in Materials Science and Engineering, 2009
- Light Transmission Aggregometry and ATP Release for the Diagnostic Assessment of Platelet FunctionSeminars in Thrombosis and Hemostasis, 2009
- Vascular bed-specific thrombosisJournal of Thrombosis and Haemostasis, 2007
- Extended DLVO theory: Electrostatic and non-electrostatic forces in oxide suspensionsAdvances in Colloid and Interface Science, 2006
- Mechanism of venous valve closure and role of the valve in circulation: a new conceptJournal of Vascular Surgery, 2003
- Modeling Low Reynolds Number Incompressible Flows Using SPHJournal of Computational Physics, 1997
- Simulating Free Surface Flows with SPHJournal of Computational Physics, 1994
- A numerical approach to the testing of the fission hypothesisThe Astronomical Journal, 1977