HLA-VBSeq v2: improved HLA calling accuracy with full-length Japanese class-I panel
Open Access
- 19 June 2019
- journal article
- research article
- Published by Springer Nature in Human Genome Variation
- Vol. 6 (1) , 1-5
Abstract
HLA-VBSeq is an HLA calling tool developed to infer the most likely HLA types from high-throughput sequencing data. However, there is still room for improvement in specific genetic groups because of the diversity of HLA alleles in human populations. Here, we present HLA-VBSeq v2, a software application that makes use of a new Japanese HLA reference panel to enhance calling accuracy for Japanese HLA class-I genes. Our analysis showed significant improvements in calling accuracy in all HLA regions, with prediction accuracies achieving over 99.0, 97.8, and 99.8% in HLA-A, B and C, respectively.Keywords
Funding Information
- Japan Agency for Medical Research and Development (JP17km0405205)
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