Linkage of the Preimplantation-Embryo-Development (Ped) Gene to the Mouse Major Histocompatibility Complex (MHC)1
Authors:
- Carol M. WarnerCWCarol M. Warner
- Sandra O. GollnickSGSandra O. Gollnick
- Simon B. GoldbardSGSimon B. Goldbard
- 1 April 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 36 (3) , 606-610
Abstract
The preimplantation-embryo-development (Ped) gene influences the rate of cleavage division of preimplantation mouse embryos. The location of the Ped gene in the mouse major histocompatibility complex (MHC), the H-2 complex, has been inferred from the analysis of cleavage rates of embryos from mouse strains congenic at the H-2 complex. In this paper, formal genetic linkage studies were undertaken to evaluate linkage of the Ped gene to the H-2 complex. Co-segregation of Ped gene phenotype and H-2 haplotype was found in back-cross embryos. These data support the hypothesis that the Ped gene is linked to the H-2 complex.Keywords
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